Gut-Brain Axis

September 17, 2018

   For this edition of Educational Empowerment we are highlighting research from the journal Scientific Reports; a NatureResearch Journal published May 2017.  The study focused on how gut microbiota affect the progression of Alzheimer's Disease.  

 

                         

 

                                   

 

                                                   Background:

 

                                                                                      

             More research lately has been focusing on how the population & diversity of how the microorganisms (bacteria) in your gut affects all aspects of your health.The anti bacterial movement started in the 1860s by Louis Pasteur lead us to believe all microorganisms are inherently bad. By the second half the 20th century the pendulum had swung too far creating hyper-sterilized environments.  It turns out not all the microorganisms in our environment are bad, and regular exposure to these microorganisms are necessary to for the normal function of our body.  

 

 

 

 

              Me is really We.  Now we realize that the human body is really an ecosystem composed of symbiotic relationships between the host(you) and the microorganism in your body.  The microorganisms in our gut conduct necessary functions like create & digest certain proteins, produce neurotransmitters, enzymes, and essential vitamins like vitamin K.

                                                                                        

 

          Microbiota modulation counteracts Alzheimer's disease progression influencing neuronal proteolysis and gut hormones plasma levels.

 

 

Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the treatment of central nervous system-related pathologies, such as Alzheimer's disease (AD). Current AD treatments aim to prevent onset, delay progression and ameliorate symptoms. 

 

In this work, 3xTg-AD mice in the early stage of AD were treated with SLAB51 probiotic formulation, thereby affecting the composition of gut microbiota and its metabolites. This influenced plasmaconcentration of inflammatory cytokines and key metabolic hormones considered therapeutic targets in neurodegeneration. Treated mice showed partial restoration of two impaired neuronal proteolytic pathways (the ubiquitin proteasome system and autophagy). Their cognitive decline was decreased compared with controls, due to a reduction in brain damage and reduced accumulation of amyloid beta aggregates.

 

 Collectively, our results clearly prove that modulation of the microbiota induces positive effects on neuronal pathways that are able to slow down the progression of Alzheimer's disease.

 

                                 

 

                                                       Dr. Van's Reflection

 

         I have read a lot of research articles in my life and I cannot remember a time when I've seen the word prove in a conclusion.  Most of the time it is suggest, indicate, illustrate, demonstrate etc. but never have I seen PROVE.  In science that is the boldest claim that can be made.  These researchers must be ultra confident in their findings from this study.  

        More and more of science & medicine is looking at the importance of the gut and its inhabitants.  The evidence is overwhelming on the power of the gut. Alzheimer's has been traditionally thought of as brain disease but based on studies like these it is obviously more complicated.  Healthcare is looking more toward an integrative approach that looks at the body as a whole.  

         This is an exciting finding because we are in control and able to alter the environment of our gut to promote the presence of good bacteria.  We are also able to intentional consume good bacteria in the form of probiotics either with food or supplementation.  The illustration below highlights examples of good and bad bacteria. 

                                                                     

 

 

                                              How to pick a good probiotic supplement?

 

                   When looking for a probiotic supplement one thing is paramount; diversity.  At Gravity Spinal Chiropractic we recommend Ortho Biotic a probiotic supplement from Ortho Molecular.  Ortho Biotic consists of 6 strains of bacteria and 1 yeast strain all specifically chosen for their benefits. 

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